Friedreich's ataxia medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Pharmacologic medical therapy is recommended among patients with Friedreich's ataxia but their affect in decrease the symptoms of Friedreich's ataxia is not significant. Pharmacologic medical therapies for Friedreich's ataxia include Physostigmine, Riluzole and Amantadine. The rationale for evaluating physostigmine in ataxia, including Friedreich's ataxia, is its inhibition of acetylcholinesterase, which prolongs central and peripheral effects of acetylcholine. The mechanism of action of Riluzole may be related to the small conductance calcium-activated potassium channels that appear to regulate excitability in neurons found within deep cerebellar nuclei. Amantadine may be helpfull in the treatment of the patients with Freidreich's ataxia.
Medical Therapy
- Pharmacologic medical therapy is recommended among patients with Friedreich's ataxia but their affect in decrease the symptoms of Friedreich's ataxia is not significant.[1]
- Pharmacologic medical therapies for Friedreich's ataxia include Physostigmine, Riluzole and Amantadine.
• Physostigmine
The rationale for evaluating physostigmine in ataxia, including Friedreich's ataxia, is its inhibition of acetylcholinesterase, which prolongs central and peripheral effects of acetylcholine.[1]
• Riluzole
The mechanism of action of Riluzole may be related to the small conductance calcium-activated potassium channels that appear to regulate excitability in neurons found within deep cerebellar nuclei.
• Amantadine
Amantadine may be helpfull in the treatment of the patients with Freidreich's ataxia.