Focal segmental glomerulosclerosis laboratory findings

Jump to navigation Jump to search

Focal segmental glomerulosclerosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Focal segmental glomerulosclerosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X-Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Focal segmental glomerulosclerosis laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Focal segmental glomerulosclerosis laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Focal segmental glomerulosclerosis laboratory findings

CDC on Focal segmental glomerulosclerosis laboratory findings

Focal segmental glomerulosclerosis laboratory findings in the news

Blogs on Focal segmental glomerulosclerosis laboratory findings

Directions to Hospitals Treating Focal segmental glomerulosclerosis

Risk calculators and risk factors for Focal segmental glomerulosclerosis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [3]

Overview

Initial lab-work up should be directed first towards finding a possible etiology for FSGS. HIV testing in patients with new-onset FSGS, especially those with collapsing variant, is a must in all patient. Additionally, monitoring of disease progression by serum creatinine and proteinuria is equally important.

Laboratory Findings

A comprehensive lab workup is necessary for all patients with FSGS. Common causes of secondary FSGS, such as HIV, HBV, HCV, and systemic lupus erythematosus (SLE), should also be ruled out. Laboratory findings consistent with the diagnosis of focal segmental glomerulosclerosis include:[1][2]

  • CBC
    • Anemia
  • Lipid profile
    • Hyperlipidemia
  • Renal function test
    • Increased creatinine levels
    • Hypoalbuminemia
  • Blood urea nitrogen (BUN)
  • CD4 count and HIV test
  • DNA/PCR for parvovirus B19
  • CMV test
  • Serum complement C3 and C4
  • ANA profile
  • Titers of antibodies specific for systemic diseases, such as anti-dsDNA
  • c-ANCA and p-ANCA
  • Serum protein electrophoresis
  • Urine analysis
    • Proteinuria
    • Microscopic hematuria
    • Dysmorphic red blood cells
    • Fatty casts
    • Microalbuminuria and urinary creatinine
    • Urine culture
    • Urinary protein electrophoresis

References

  1. Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH; et al. (2013). "KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis". Am J Kidney Dis. 62 (3): 403–41. doi:10.1053/j.ajkd.2013.06.002. PMID 23871408.
  2. Rosenberg AZ, Kopp JB (March 2017). "Focal Segmental Glomerulosclerosis". Clin J Am Soc Nephrol. 12 (3): 502–517. doi:10.2215/CJN.05960616. PMC 5338705. PMID 28242845.

Template:WH Template:WS