Extramammary Paget's disease medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chemotherapy with either 5-fluorouracil, imiquimod cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease.

Medical Therapy

The following medical therapies have been studied for the treatment of extramammary Paget's disease:

• 5-fluorouracil
• Imiquimod
• Combination of paclitaxel and trastuzumab

Medication	Mechanism of action	Dosage
Imiquimod	These agents modulate key factors of the immune system Imiquimod is a immune response modifier with an unknown mechanism of action	Imiquimod 5% cream is applied 3 times weekly for 16 weeks.
Fluorouracil	These agents inhibit cell growth and proliferation Fluorouracil interferes with DNA synthesis by blocking methylation of deoxyuridylic acid via inhibition of thymidylate synthetase and, eventually, cell proliferation.	It is used topically
Paclitaxel	Paclitaxel's mechanism of action involves interference with the normal breakdown of microtubules during cell division
Trastuzumab	Trastuzumab is a recombinant monoclonal antibody against human epidermal growth factor receptor 2 (HER2). It is effective when tumor cells overexpress HER2 protein.

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