Emtricitabine rilpivirine tenofovir contraindications
Jump to navigation
Jump to search
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Contraindications
COMPLERA should not be coadministered with the following drugs, as significant decreases in rilpivirine plasma concentrations may occur due to CYP3A enzyme induction or gastric pH increase, which may result in loss of virologic response and possible resistance to COMPLERA or to the class of NNRTIs [See Drug Interactions (7) and Clinical Pharmacology (12.3)]:
- The anticonvulsants carbamazepine, oxcarbazepine, phenobarbital, phenytoin
- The antimycobacterials rifabutin, rifampin, rifapentine
- Proton pump inhibitors, such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole
- The glucocorticoid systemic dexamethasone (more than a single dose)
- St. John's wort (Hypericum perforatum).[1]
References
Adapted from the FDA Package Insert.