Dichloromuconate cycloisomerase

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In enzymology, a dichloromuconate cycloisomerase (EC 5.5.1.11) is an enzyme that catalyzes the chemical reaction

2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate 2,4-dichloro-cis,cis-muconate

Hence, this enzyme has one substrate, 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate, and one product, 2,4-dichloro-cis,cis-muconate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). This enzyme participates in 1,4-dichlorobenzene degradation. It employs one cofactor, manganese.

References

  • IUBMB entry for 5.5.1.11
  • BRENDA references for 5.5.1.11 (Recommended.)
  • PubMed references for 5.5.1.11
  • PubMed Central references for 5.5.1.11
  • Google Scholar references for 5.5.1.11
  • Kuhm AE, Schlomann M, Knackmuss HJ, Pieper DH (1990). "Purification and characterization of dichloromuconate cycloisomerase from Alcaligenes eutrophus JMP 134". Biochem. J. 266: 877&ndash, 83. PMID 2327971.

External links

The CAS registry number for this enzyme class is 126904-95-8.

Gene Ontology (GO) codes


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