Dicarboxylate-CoA ligase

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In enzymology, a dicarboxylate-CoA ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + an alphaomega-dicarboxylic acid + CoA AMP + diphosphate + an omega-carboxyacyl-CoA

The 3 substrates of this enzyme are ATP, alphaomega-dicarboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and omega-carboxyacyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is omega-dicarboxylate:CoA ligase (AMP-forming). Other names in common use include carboxylyl-CoA synthetase, and dicarboxylyl-CoA synthetase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Vamecq J, de Hoffmann E, Van Hoof F (1985). "The microsomal dicarboxylyl-CoA synthetase". Biochem. J. 230: 683&ndash, 93. PMID 4062873.

External links

The CAS registry number for this enzyme class is 99332-77-1.

Gene Ontology (GO) codes