Diamine N-acetyltransferase

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In enzymology, a diamine N-acetyltransferase (EC 2.3.1.57) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an alkane-alpha,omega-diamine CoA + an N-acetyldiamine

Thus, the two substrates of this enzyme are acetyl-CoA and alkane-alpha,omega-diamine, whereas its two products are CoA and N-acetyldiamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase. Other names in common use include spermidine acetyltransferase, putrescine acetyltransferase, putrescine (diamine)-acetylating enzyme, diamine acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine N1-acetyltransferase, acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, putrescine acetylase, and putrescine N-acetyltransferase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 2B3U, 2B3V, 2B4B, 2B4D, 2B58, 2B5G, 2BEI, 2F5I, 2FXF, 2G3T, 2JEV, and 2Q4V.

References

  • IUBMB entry for 2.3.1.57
  • BRENDA references for 2.3.1.57 (Recommended.)
  • PubMed references for 2.3.1.57
  • PubMed Central references for 2.3.1.57
  • Google Scholar references for 2.3.1.57
  • Ragione FD, Pegg AE (1982). "Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver". Biochemistry. 21: 6152&ndash, 8. PMID 7150547.

External links

The CAS registry number for this enzyme class is 54596-36-0.

Gene Ontology (GO) codes


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