Dexh-box helicase 34

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

DExH-box helicase 34 is a protein that in humans is encoded by the DHX34 gene.

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008].

Further reading

• Longman D, Hug N, Keith M, Anastasaki C, Patton EE, Grimes G, Cáceres JF (September 2013). "DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans". Nucleic Acids Res. 41 (17): 8319–31. doi:10.1093/nar/gkt585. PMC 3783168. PMID 23828042.
• Hug N, Cáceres JF (September 2014). "The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex". Cell Rep. 8 (6): 1845–1856. doi:10.1016/j.celrep.2014.08.020. PMC 4534575. PMID 25220460.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.