Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene .
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Function DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).
References Further reading
Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem . 278 (24): 21930–7. doi :10.1074/jbc.M301157200 . PMID 12670957 . Juszczynski P, Kutok JL, Li C, Mitra J, Aguiar RC, Shipp MA (2006). "BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate" . Mol. Cell. Biol . 26 (14): 5348–59. doi :10.1128/MCB.02351-05 . PMC 1592708 PMID 16809771 . Wilting SM, de Wilde J, Meijer CJ, Berkhof J, Yi Y, van Wieringen WN, Braakhuis BJ, Meijer GA, Ylstra B, Snijders PJ, Steenbergen RD (2008). "Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer" . Genes Chromosomes Cancer . 47 (10): 890–905. doi :10.1002/gcc.20590 . PMC 2733213 PMID 18618715 . Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP, Shipp MA (2009). "BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response" . Mol. Cell . 36 (1): 110–20. doi :10.1016/j.molcel.2009.08.019 . PMC 2913878 PMID 19818714 . Obiero J, Walker JR, Dhe-Paganon S (2012). "Fold of the conserved DTC domain in Deltex proteins". Proteins . 80 (5): 1495–9. doi :10.1002/prot.24054 . PMID 22411408 . Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, Shipp MA (2013). "BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8" . Mol. Cell. Biol . 33 (4): 845–57. doi :10.1128/MCB.00990-12 . PMC 3571337 PMID 23230272 . Holleman J, Marchese A (2014). "The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4" . Mol. Biol. Cell . 25 (12): 1892–904. doi :10.1091/mbc.E13-10-0612 . PMC 4055268 PMID 24790097 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
