Dehydroemetine adverse effects
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| Dehydroemetine |
|---|
| MEBADIN® Prescribing Information |
| General Information |
| Clinical Information |
| Dosage and Administration |
| Precautions |
| Use in Pregnancy |
| Adverse Effects |
| Drug Interactions |
| Storage |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Adverse Effects
Local Reactions
The injections are painful. Abscess formation is common. A local eczematous rash may follow inadvertent subcutaneous injection. Generalized urticarial and purpuric rashes are rare.
Neuromuscular Effects
Weakness and muscular pain are common, particularly in the limbs and neck. Dyspnoea may also occur as a result of generalized weakness. These symptoms are dose-related and often precede evidence of cardiotoxicity.
Cardiac Effects
Hypotension, precordial pain, tachycardia and dysrhythmias are the most frequent signs of cardiac impairment. Electrocardiographic changes, particularly flattening and inversion of the T wave and prolongation of the Q-T interval, provide an early indication of toxicity.[1]