Corneodesmosin

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Corneodesmosin is a protein that in humans is encoded by the CDSN gene.[1][2][3]

This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.[3]

See also

References

  1. Simon M, Montezin M, Guerrin M, Durieux JJ, Serre G (Jan 1998). "Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes". J Biol Chem. 272 (50): 31770–6. doi:10.1074/jbc.272.50.31770. PMID 9395522.
  2. Zhou Y, Chaplin DD (Nov 1993). "Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation". Proc Natl Acad Sci U S A. 90 (20): 9470–4. doi:10.1073/pnas.90.20.9470. PMC 47590. PMID 8415725.
  3. 3.0 3.1 "Entrez Gene: CDSN corneodesmosin".

Further reading




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