Chronic bronchitis Lung Transplant

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]

Overview

Lung transplant is primarily done for improvement of symptoms and quality of life. COPD is the leading cause of lung trasplant. Certain criteria have been developed to standardize this approach.

Lung Transplant

Due to the chronic nature of this disease some patients may be qualified for lung transplantation. COPD is considered as the most common indication for lung transplantation.^[1]

Indications

BODE index of 7 to 10 or at least 1 of the following:

History of hospitalization for exacerbation associated with acute hypercapnia (PCO2 > 50 mmHg)
Pulmonary hypertension or cor pulmonale, or both, despite oxygen therapy
FEV1 < 20% and either DlCO < 20% or homogeneous distribution of emphysema^[2]

Contraindications

Recent malignancy (other than nonmelanoma skin cancer)
Active infection with hepatitis B or C virus associated with histologic evidence of significant liver damage
Active or recent cigarette smoking, drug abuse, or alcohol abuse
Severe psychiatric illness
Repeated noncompliance with medical care
Absence of a consistent and reliable social support network
HIV infection (in some centers AIDS is considered as absolute contraindication)

References

↑ Yusen RD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Dobbels F, Goldfarb SB, Levvey BJ, Lund LH, Meiser B, Stehlik J (2014). "The registry of the International Society for Heart and Lung Transplantation: thirty-first adult lung and heart-lung transplant report--2014; focus theme: retransplantation". J. Heart Lung Transplant. 33 (10): 1009–24. doi:10.1016/j.healun.2014.08.004. PMID 25242125.
↑ Kreider M, Hadjiliadis D, Kotloff RM (2011). "Candidate selection, timing of listing, and choice of procedure for lung transplantation". Clin. Chest Med. 32 (2): 199–211. doi:10.1016/j.ccm.2011.02.001. PMID 21511083.

[pmid25242125-1] Yusen RD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Dobbels F, Goldfarb SB, Levvey BJ, Lund LH, Meiser B, Stehlik J (2014). "The registry of the International Society for Heart and Lung Transplantation: thirty-first adult lung and heart-lung transplant report--2014; focus theme: retransplantation". J. Heart Lung Transplant. 33 (10): 1009–24. doi:10.1016/j.healun.2014.08.004. PMID 25242125.

[pmid21511083-2] Kreider M, Hadjiliadis D, Kotloff RM (2011). "Candidate selection, timing of listing, and choice of procedure for lung transplantation". Clin. Chest Med. 32 (2): 199–211. doi:10.1016/j.ccm.2011.02.001. PMID 21511083.

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[2]