Chondroitin-glucuronate 5-epimerase

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In enzymology, a chondroitin-glucuronate 5-epimerase (EC is an enzyme that catalyzes the chemical reaction

chondroitin D-glucuronate dermatan L-iduronate

Hence, this enzyme has one substrate, chondroitin D-glucuronate, and one product, dermatan L-iduronate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is chondroitin-D-glucuronate 5-epimerase. Other names in common use include polyglucuronate 5-epimerase, dermatan-sulfate 5-epimerase, urunosyl C-5 epimerase, and chondroitin D-glucuronosyl 5-epimerase. This enzyme participates in chondroitin sulfate biosynthesis.


  • IUBMB entry for
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  • PubMed references for
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  • Malmstrom A, Aberg L (1982). "Biosynthesis of dermatan sulphate. Assay and properties of the uronosyl C-5 epimerase". Biochem. J. 201: 489&ndash, 93. PMID 7092807.

External links

The CAS registry number for this enzyme class is 86417-91-6.

Gene Ontology (GO) codes