Carboxyvinyl-carboxyphosphonate phosphorylmutase

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In enzymology, a carboxyvinyl-carboxyphosphonate phosphorylmutase (EC is an enzyme that catalyzes the chemical reaction

1-carboxyvinyl carboxyphosphonate 3-(hydrohydroxyphosphoryl)pyruvate + CO2

Hence, this enzyme has one substrate, 1-carboxyvinyl carboxyphosphonate, and two products, 3-(hydrohydroxyphosphoryl)pyruvate and CO2.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QIW.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Pollack SJ, Freeman S, Pompliano DL, Knowles JR (1992). "Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus". Eur. J. Biochem. 209: 735&ndash, 43. PMID 1330557.
  • Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ (1987). "Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus". J. Bacteriol. 169: 3482&ndash, 8. PMID 3611020.

External links

The CAS registry number for this enzyme class is 122799-57-9.

Gene Ontology (GO) codes