Carbonyl reductase (NADPH)

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Ribbon diagram of human carbonyl reductase 1, in complex with NADPH and a small molecule inhibitor (not shown). From PDB: 1WMA​.

In enzymology, a carbonyl reductase (NADPH) (EC 1.1.1.184) is an enzyme that catalyzes the chemical reaction

R-CHOH-R' + NADP+ R-CO-R' + NADPH + H+

Thus, the two substrates of this enzyme are R-CHOH-R' and NADP+, whereas its 3 products are R-CO-R', NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is secondary-alcohol:NADP+ oxidoreductase. Other names in common use include aldehyde reductase 1, prostaglandin 9-ketoreductase, xenobiotic ketone reductase, NADPH-dependent carbonyl reductase, ALR3, carbonyl reductase, nonspecific NADPH-dependent carbonyl reductase, aldehyde reductase 1, and carbonyl reductase (NADPH). This enzyme participates in arachidonic acid metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1CYD, 1WMA, 2HRB, and 2PFG.

References

  • IUBMB entry for 1.1.1.184
  • BRENDA references for 1.1.1.184 (Recommended.)
  • PubMed references for 1.1.1.184
  • PubMed Central references for 1.1.1.184
  • Google Scholar references for 1.1.1.184
  • Ahmed NK, Felsted RL, Bachur NR (1978). "Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers". Biochem. Pharmacol. 27: 2713&ndash, 9. PMID 31888.
  • Lin YM, Jarabak J (1978). "Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition". Biochem. Biophys. Res. Commun. 81: 1227&ndash, 34. PMID 666816.
  • Wermuth B (1981). "Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase". J. Biol. Chem. 256: 1206&ndash, 13. PMID 7005231.

External links

The CAS registry number for this enzyme class is 89700-36-7.

Gene Ontology (GO) codes


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