Carbonyl reductase (NADPH)
- R-CHOH-R' + NADP+ R-CO-R' + NADPH + H+
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is secondary-alcohol:NADP+ oxidoreductase. Other names in common use include aldehyde reductase 1, prostaglandin 9-ketoreductase, xenobiotic ketone reductase, NADPH-dependent carbonyl reductase, ALR3, carbonyl reductase, nonspecific NADPH-dependent carbonyl reductase, aldehyde reductase 1, and carbonyl reductase (NADPH). This enzyme participates in arachidonic acid metabolism.
- IUBMB entry for 184.108.40.206
- BRENDA references for 220.127.116.11 (Recommended.)
- PubMed references for 18.104.22.168
- PubMed Central references for 22.214.171.124
- Google Scholar references for 126.96.36.199
- Ahmed NK, Felsted RL, Bachur NR (1978). "Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers". Biochem. Pharmacol. 27: 2713&ndash, 9. PMID 31888.
- Lin YM, Jarabak J (1978). "Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition". Biochem. Biophys. Res. Commun. 81: 1227&ndash, 34. PMID 666816.
- Wermuth B (1981). "Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase". J. Biol. Chem. 256: 1206&ndash, 13. PMID 7005231.
- The CAS registry number for this enzyme class is 89700-36-7.
Gene Ontology (GO) codes
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