Carbon monoxide poisoning

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Overview

Carbon monoxide poisoning occurs after the inhalation of carbon monoxide gas. Carbon monoxide (CO) is a product of combustion of organic matter under conditions of restricted oxygen supply, which prevents complete oxidation to carbon dioxide (CO2). Carbon monoxide is colorless, odorless, tasteless, and non-irritating, making it difficult to detect. Carbon monoxide is a significantly toxic gas with poisoning being the most common type of fatal poisoning in many countries.[1] Symptoms of mild poisoning include headaches and flu-like effects; larger exposures can lead to significant toxicity of the central nervous system and heart. Following poisoning, long-term sequelae often occur. Carbon monoxide can also have severe effects on the fetus of a pregnant woman. The mechanisms by which carbon monoxide produces toxic effects are not yet fully understood, but hemoglobin, myoglobin, and mitochondrial cytochrome oxidase are thought to be compromised. Treatment largely consists of administering 100% oxygen or hyperbaric oxygen therapy, although the optimum treatment remains controversial.[2] Domestic carbon monoxide poisoning can be prevented by the use of household carbon monoxide detectors.

Historical perspective

  • In 1921, Dr. William Wilmer, an ophthalmologist published a case in American journal of ophthalmology in which he described the experiences of a family with similar symptoms as mentioned above.[3]
  • In 2005, a report was published describing a young female of age 23, found delirious and hyperventilating, as a result of leakage and accumulation of gas from the heater. She believed to have seen a 'ghost' in the shower. [4]

Sources

  • Main sources of CO that are responsible for environmental pollution are house hold fires, heaters, furnaces, motor vehicle exhaust, propane fueled equipment (such as ice resurfacers, forklifts), engine-driven generators, and wood burning stove.[5][6]
  • CO poisoning can also occur in scuba diving due to malfunctioning of diving air compressors.
  • Another source is exposure to the organic solvent methylene chloride, which is metabolized to CO by the body.[7]
  • Polluted air often contains unhealthy levels of carbon monoxide. Many areas of the US have struggled to achieve legislated limits. Significant advances have been made since the implementation by 1990 of a vehicle emissions limit of 3.4 gpm (grams per mile), a large reduction from the previous limit of 87 gpm.[8]

Pathophysiology

The precise mechanisms by which toxic effects are induced by CO are not fully understood. It may damage the body in one of the following ways:[9]

CO and Hemoglobin

  • Because hemoglobin is a tetramer with four oxygen binding sites, binding of CO at one of these sites also increases the oxygen affinity of the remaining 3 sites, which interferes with normal release of oxygen. This causes hemoglobin to retain oxygen that would otherwise be delivered to the tissue.[14]
  • Amount of oxygen available for tissue use are decreased. This situation is described as CO shifting the oxygen dissociation curve to the left. Blood oxygen content is actually increased in the case of carbon monoxide poisoning; because all the oxygen is in the blood, none is being given to the tissues, and this causes tissue hypoxic injury.
CO dissociation curve Source:Case courtesy of By Hazmat2, via Wikimedia Commons


CO and Myoglobin

  • CO has 60 times greater affinity to myoglobin as compared to oxygen. It can bind readily to myoglobin, which is another heme-containing protein, abundantly present in the muscles of body.
  • Binding of CO to myoglobin markedly reduces its oxygen carrying capacity, leading to decrease in cardiac output, hypotension which ultimately resulting in cerebral ischemia.
  • CO bound to myolobin is later released in the body, which subsequently binds with the hemoglobin. This phenomenon is responsible for delayed return of symptoms in CO poisoning. [15]

CO and Mitochondrial Cytochrome Oxidase C

Epidemiology & Demographics

  • Carbon monoxide poisoning is the most common type of fatal poisoning in France and the United States. It has been estimated that more than 40,000 people per year seek medical attention for carbon monoxide poisoning in the United States.[17]
  • In many industrialized countries, carbon monoxide may be the cause of greater than 50% of fatal poisonings.
  • In the U.S., about 200 people die each year from carbon monoxide poisoning associated with home fuel-burning heating equipment. The CDC reports, "Each year, more than 500 Americans die from unintentional CO poisoning, and more than 2,000 commit suicide by intentionally poisoning themselves."[18]

CO and Suicide

  • Carbon monoxide has emerged as a common mean of suicide by poisoning, since the placement of strict legal restrictions on poisons like cyanide and arsenic.
  • Suicide was also often committed by inhaling exhaust fumes of running car engines. In the past, motor car exhaust may have contained up to 25% carbon monoxide. However, newer cars have catalytic converters, which can eliminate over 99% of carbon monoxide produced.[19] However, even cars with catalytic converters can produce substantial carbon monoxide if an idling car is left in an enclosed space. This is due to reduced oxygen availability, and therefore, less efficient combustion.
  • As carbon monoxide poisoning via car exhaust has become less of a suicide option, there has been an increase in new methods of carbon monoxide poisoning such as burning charcoal or other fossil fuels within a confined space, such as a small room, tent, or car.[20]

Toxicity

  • Carbon monoxide is a significantly toxic gas, although patients may demonstrate varied clinical manifestations with different outcomes, even under similar exposure conditions.[21]

Risk factors

Classification:

  • The degrees of poisoning have been described as mild, moderate, and severe based on carboxyhaemoglobin percentage levels and clinical symptoms.:[22]
    • Mild carbon monoxide poisoning: Carboxyhaemoglobin level of over 10% without clinical signs or symptoms of carbon monoxide poisoning.
  • Levels of carbon monoxide bound in the blood can be determined by measuring carboxyhaemoglobin, which is a stable complex of carbon monoxide and hemoglobin that forms in red blood cells.
  • Carbon monoxide also functions as a neurotransmitter.
  • Normal carboxyhemoglobin levels in an average person are less than 5%, whereas cigarette smokers (two packs/day) may have levels up to 9%.[23]
  • Serious toxicity is often associated with carboxyhemoglobin levels above 25%, and the risk of fatality is high with levels over 70%. Still, no consistent dose response relationship has been found between carboxyhemoglobin levels and clinical effects.[24]
  • Hence, carboxyhemoglobin levels are better guide for exposure levels than effects as they do not reliably predict clinical course or short- or long-term outcome.[25]
  • The effects of carbon monoxide in parts per million are listed below:[26]
    • 35 ppm (0.0035%): Headache and dizziness within six to eight hours of constant exposure.
    • 100 ppm (0.01%): Slight headache in two to three hours.
    • 200 ppm (0.02%): Slight headache within two to three hours.
    • 400 ppm (0.04%): Frontal headache within one to two hours.
    • 800 ppm (0.08%): Dizziness, nausea, and convulsions within 45 minutes. Insensible within two hours.
    • 1,600 ppm (0.16%): Headache, dizziness, and nausea within 20 minutes. Death in less than two hours.
    • 3,200 ppm (0.32%): Headache, dizziness and nausea in five to ten minutes. Death within 30 minutes.
    • 6,400 ppm (0.64%): Headache and dizziness in one to two minutes. Death in less than 20 minutes.
    • 12,800 ppm (1.28%): Unconsciousness after 2-3 breaths. Death in less than three minutes.
  • In addition, a recent report concludes that carbon monoxide exposure can lead to a decrease in lifespan significantly as a result of damaged myocardium.[27]

Signs and Symptoms

Carbon monoxide poisoning is particularly difficult to diagnose since it is not easily detected by human senses. Since CO poisoning is a diagnosis frequently overlooked, it is overly emphasized to measure carboxyhemoglobin in suspicious cases. The clinical manifestations include :

Acute

Most common:

Common symptoms of acute CO poisoning include:[28]

Less common

Less common symptoms of acute CO poisoning are as follows:[29]

Delayed

CO poisoning may cause delayed clinical manifestations in the form of severe neurological manifestations.These symptoms occur days or even weeks after an acute poisoning epispde. Common clinical manifestations include:[30][31]

Chronic

Long term, repeat exposures present a greater risk to individuals with coronary heart disease and in pregnant patients.[32] Chronic exposure may increase the incidence of cardiovascular symptoms in some workers, such as motor vehicle examiners, firefighters, and welders. Patients often complain of:[33]

. Upon removal from exposure, the symptoms usually resolve themselves.[34]

Treatment

Emergency menagement

Emergency management for carbon monoxide poisoning include:

  • Immediately remove the victim from the site of exposure, without endangering oneself
  • Call for help
  • Start CPR if needed

Medical treatment

Prevention

Primary Prevention

  • Effective measures for primary prevention of CO poisonong include:
  • Public education on the safe operation of appliances, heaters, fireplaces, and internal-combustion engines
  • Installation of carbon monoxide detectors.
    • Carbon monoxide alarms are usually installed in homes around heaters and other equipment.
    • If a high level of CO is detected, the device sounds an alarm, giving people in the area a chance to ventilate the area or safely leave the building. Unlike smoke detectors, they do not need to be placed near ceiling level.
    • The Consumer Product Safety Commission says that "carbon monoxide detectors are as important to home safety as smoke detectors are," and recommends that each home should have at least one carbon monoxide detector.
    • The devices, which retail for USD $20-$60 and are widely available, can either be battery-operated or AC powered (with or without a battery backup). Since CO is colorless and odorless (unlike smoke from a fire), detection in a home environment is impossible without such a warning device.
    • Some state and municipal governments, including those of Ontario, Canada, and New York City, require installation of CO detectors in new units. Massachusetts and Illinois began to require a detector in all residences on January 1, 2007.
  • The carbon monoxide can be easily detected by the filtering paper impregnated by the solution of the palladium chloride. Carbon monoxide reduces the palladium monoxide to the black metallic palladium. This reaction is very sensitive.

See also

Resources

References

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  2. 2.0 2.1 Buckley NA, Isbister GK, Stokes B, Juurlink DN. (2005). "Hyperbaric oxygen for carbon monoxide poisoning : a systematic review and critical analysis of the evidence". Toxicol Rev. 24 (2): 75–92. PMID 16180928.
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  7. Kubic VL, Anders MW. (1975). "Metabolism of dihalomethanes to carbon monoxide. II. In vitro studies". Drug Metab Dispos. 3 (2): 104–12. PMID 236156.
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  10. Culnan DM, Craft-Coffman B, Bitz GH, Capek KD, Tu Y, Lineaweaver WC; et al. (2018). "Carbon Monoxide and Cyanide Poisoning in the Burned Pregnant Patient: An Indication for Hyperbaric Oxygen Therapy". Ann Plast Surg. doi:10.1097/SAP.0000000000001351. PMID 29461288.
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  12. Alonso JR, Cardellach F, López S, Casademont J, Miró O (2003). "Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain". Pharmacol Toxicol. 93 (3): 142–6. PMID 12969439.
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  36. Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, Orme JF Jr, Thomas FO, Morris AH. (2002). "Hyperbaric oxygen for acute carbon monoxide poisoning". N Engl J Med. 347 (14): 1057–67. PMID 12362006.
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  38. Ducasse JL, Celsis P, Marc-Vergnes JP. (1995). "Non-comatose patients with acute carbon monoxide poisoning: hyperbaric or normobaric oxygenation?". Undersea Hyperb Med. 22 (1): 9–15. PMID 7742714. Text " pdf" ignored (help)

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