Calcium-induced calcium release

Jump to: navigation, search

Calcium-induced calcium release (CICR) is a mechanism of calcium release from muscle sarcoplasmic reticulum that was proposed in the 1970s[1]. Originally proposed for skeletal muscle, subsequent research has revealed that it is actually the predominant mechanism in cardiac muscle.

CICR in Excitation-Contraction (EC) Coupling

The mechanism that couples excitation - an action potential in the plasma membrane of the muscle cell - and contraction of heart muscle is an increase in the cell's cystolic calcium concentration. This calcium combines with the regulator protein troponin, initiatin cross-bridge formation between actin and myosin.

The Paradox of Regenerative Release

Termination of CICR


  1. Endo M. (1977). "Calcium release from the sarcoplasmic reticulum". Physiol Rev. 57 (1): 71–108. PMID 13441.