CTSE

Cathepsin E
PDB rendering based on 1tzs.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1tzs​
Identifiers
Symbols	CTSE ; CATE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37551
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cathepsin E, also known as CTSE, is a human gene.

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.

Further reading

• Tsukuba T, Yamamoto K (2003). "[Atopic dermatitis and cathepsin E]". Nippon Yakurigaku Zasshi. 122 (1): 15–20. PMID 12843568.
• Flynn TJ, Deshmukh DS, Pieringer RA (1977). "Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain". J. Biol. Chem. 252 (16): 5864–70. PMID 195962.CS1 maint: Multiple names: authors list (link)
• Azuma T, Liu WG, Vander Laan DJ; et al. (1992). "Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32". J. Biol. Chem. 267 (3): 1609–14. PMID 1370478.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saku T, Sakai H, Shibata Y; et al. (1992). "An immunocytochemical study on distinct intracellular localization of cathepsin E and cathepsin D in human gastric cells and various rat cells". J. Biochem. 110 (6): 956–64. PMID 1794985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Athauda SB, Takahashi T, Inoue H; et al. (1992). "Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin". FEBS Lett. 292 (1–2): 53–6. PMID 1959628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lees WE, Kalinka S, Meech J; et al. (1990). "Generation of human endothelin by cathepsin E.". FEBS Lett. 273 (1–2): 99–102. PMID 2226872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Athauda SB, Matsuzaki O, Kageyama T, Takahashi K (1990). "Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E.". Biochem. Biophys. Res. Commun. 168 (2): 878–85. PMID 2334440.CS1 maint: Multiple names: authors list (link)
• Couvreur JM, Azuma T, Miller DA; et al. (1990). "Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids". Cytogenet. Cell Genet. 53 (2–3): 137–9. PMID 2369841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Azuma T, Pals G, Mohandas TK; et al. (1989). "Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases". J. Biol. Chem. 264 (28): 16748–53. PMID 2674141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fowler SD, Kay J, Dunn BM, Tatnell PJ (1995). "Monomeric human cathepsin E.". FEBS Lett. 366 (1): 72–4. PMID 7789521.CS1 maint: Multiple names: authors list (link)
• Finley EM, Kornfeld S (1995). "Subcellular localization and targeting of cathepsin E.". J. Biol. Chem. 269 (49): 31259–66. PMID 7983070.
• Takeda-Ezaki M, Yamamoto K (1993). "Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes". Arch. Biochem. Biophys. 304 (2): 352–8. PMID 8346912.
• Schulz TF, Reeves JD, Hoad JG; et al. (1993). "Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage". AIDS Res. Hum. Retroviruses. 9 (2): 159–66. PMID 8457383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finzi G, Cornaggia M, Capella C; et al. (1993). "Cathepsin E in follicle associated epithelium of intestine and tonsils: localization to M cells and possible role in antigen processing". Histochemistry. 99 (3): 201–11. PMID 8491674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Azuma T, Hirai M, Ito S; et al. (1996). "Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report". Int. J. Cancer. 67 (4): 492–7. doi:10.1002/(SICI)1097-0215(19960807)67:4<492::AID-IJC5>3.0.CO;2-N. PMID 8759606.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sealy L, Mota F, Rayment N; et al. (1996). "Regulation of cathepsin E expression during human B cell differentiation in vitro". Eur. J. Immunol. 26 (8): 1838–43. PMID 8765029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernstein HG, Reichenbach A, Wiederanders B (1998). "Cathepsin E immunoreactivity in human ocular tissues: influence of aging and pathological states". Neurosci. Lett. 240 (3): 135–8. PMID 9502222.CS1 maint: Multiple names: authors list (link)
• Cook M, Caswell RC, Richards RJ; et al. (2001). "Regulation of human and mouse procathepsin E gene expression". Eur. J. Biochem. 268 (9): 2658–68. PMID 11322887.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Tsunoda T, Sese J; et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)