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CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass295.7231 g/mol
3D model (JSmol)

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]

CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects.[2][3] It also increases appetite,[4] and reduces the development of gastrointestinal ulcers following chronic stress.[5]



  1. Leidenheimer NJ, Schechter MD. Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex. Pharmacology, Biochemistry and Behaviour. 1988 Oct;31(2):249-54. PMID 2854261
  2. Bernasconi R, Marescaux C, Vergnes M, Klebs K, Klein M, Martin P, Portet C, Maitre L, Schmutz M. Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models. Journal of Neural Transmission. 1988;71(1):11-27. PMID 3343593
  3. Rump S, Raszewski W, Gidynska T, Galecka E. Effects of CGS 9896 in acute experimental intoxication with fluostigmine. Archives of Toxicology. 1990;64(5):412-3. PMID 2206111
  4. Chen SW, Davies MF, Loew GH. Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake. Pharmacology, Biochemistry and Behaviour. 1995 Jun-Jul;51(2-3):499-503. PMID 7667375
  5. Najim RA, Karim KH. Effect of CGS 9896 on stress-induced gastric ulcer in rat. Clinical and Experimental Pharmacology and Physiology. 1990 Feb;17(2):157-161. PMID 2109664