CDP-diacylglycerol diphosphatase

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In enzymology, a CDP-diacylglycerol diphosphatase (EC is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + H2O CMP + phosphatidate

Thus, the two substrates of this enzyme are CDP-diacylglycerol and H2O, whereas its two products are CMP and phosphatidate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is CDP-diacylglycerol phosphatidylhydrolase. Other names in common use include cytidine diphosphodiacylglycerol pyrophosphatase, and CDP diacylglycerol hydrolase. This enzyme participates in glycerophospholipid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2POF.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Raetz CR, Hirschberg CB, Dowhan W, Wickner WT, Kennedy EP (1972). "A membrane-bound pyrophosphatase in Escherichia coli catalyzing the hydrolysis of cytidine diphosphate-diglyceride". J. Biol. Chem. 247: 2245&ndash, 7. PMID 4335869.

External links

The CAS registry number for this enzyme class is 62213-20-1.

Gene Ontology (GO) codes