Bloom-Richardson grade
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
The Bloom-Richardson grade (BR grade) is a a histologic grade assigned by pathologists to breast cancers. It is the most common type of cancer grade system currently used. It is a semi-quantitative grading method based on three morphologic features of invasive breast cancers. The morphologic features that are used are:
- degree of tumor tubule formation (percentage of cancer composed of tubular structures)
- tumor mitotic activity (rate of cell division)
- nuclear pleomorphism of tumor cells (nuclear grade, change in cell size and uniformity)
Each of these features is assigned a score ranging from 1 to 3. The scores are then added together for a final sum that will range between 3 to 9. This value is then used to grade the tumor as follows :
- 3-5 Grade 1 tumor (well-differentiated).
- 6-7 Grade 2 tumor (moderately-differentiated).
- 8-9 Grade 3 tumor (poorly-differentiated).
References
- Bloom H, Richardson W (1957). "Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.". Br J Cancer 11 (3): 359-77. PMID 13499785.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
