Biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
- ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
The 3 substrates of this enzyme are ATP, biotin, and [[apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]]], whereas its 3 products are AMP, diphosphate, and [[[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]]].
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase, biotin-propionyl coenzyme A carboxylase synthetase, and propionyl coenzyme A holocarboxylase synthetase. This enzyme participates in biotin metabolism.
- IUBMB entry for 126.96.36.199
- BRENDA references for 188.8.131.52 (Recommended.)
- PubMed references for 184.108.40.206
- PubMed Central references for 220.127.116.11
- Google Scholar references for 18.104.22.168
- Siegel L, Foote JL and Coon MJ (1965). "The enzymatic synthesis of propionyl coenzyme A holocarboxylase from d-biotinyl 5'-adenylate and the apocarboxylase". J. Biol. Chem. 240: 1025&ndash, 1031.
- The CAS registry number for this enzyme class is 37318-67-5.