Biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase

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In enzymology, a biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and [[apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]]], whereas its 3 products are AMP, diphosphate, and [[[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]]].

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase, biotin-propionyl coenzyme A carboxylase synthetase, and propionyl coenzyme A holocarboxylase synthetase. This enzyme participates in biotin metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Siegel L, Foote JL and Coon MJ (1965). "The enzymatic synthesis of propionyl coenzyme A holocarboxylase from d-biotinyl 5'-adenylate and the apocarboxylase". J. Biol. Chem. 240: 1025&ndash, 1031.

External links

The CAS registry number for this enzyme class is 37318-67-5.

Gene Ontology (GO) codes