Biotin-(methylcrotonoyl-CoA-carboxylase) ligase

Jump to: navigation, search

In enzymology, a biotin-[methylcrotonoyl-CoA-carboxylase] ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and [[apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]]], whereas its 3 products are AMP, diphosphate, and [[[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]]].

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[methylcrotonoyl-CoA-carboxylase] synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase, beta-methylcrotonyl coenzyme A holocarboxylase synthetase, and holocarboxylase-synthetase. This enzyme participates in biotin metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Hopner T, Knappe J (1965). "[Synthesis of biotin in beta-methylcrotonyl-CoA-carboxylase by holocarboxylase synthetase]". Biochem. Z. 342: 190&ndash, 206. PMID 5867144.

External links

The CAS registry number for this enzyme class is 37318-68-6.

Gene Ontology (GO) codes