Benzidine

Jump to navigation Jump to search

Template:Chembox new

WikiDoc Resources for Benzidine

Articles

Most recent articles on Benzidine

Most cited articles on Benzidine

Review articles on Benzidine

Articles on Benzidine in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Benzidine

Images of Benzidine

Photos of Benzidine

Podcasts & MP3s on Benzidine

Videos on Benzidine

Evidence Based Medicine

Cochrane Collaboration on Benzidine

Bandolier on Benzidine

TRIP on Benzidine

Clinical Trials

Ongoing Trials on Benzidine at Clinical Trials.gov

Trial results on Benzidine

Clinical Trials on Benzidine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Benzidine

NICE Guidance on Benzidine

NHS PRODIGY Guidance

FDA on Benzidine

CDC on Benzidine

Books

Books on Benzidine

News

Benzidine in the news

Be alerted to news on Benzidine

News trends on Benzidine

Commentary

Blogs on Benzidine

Definitions

Definitions of Benzidine

Patient Resources / Community

Patient resources on Benzidine

Discussion groups on Benzidine

Patient Handouts on Benzidine

Directions to Hospitals Treating Benzidine

Risk calculators and risk factors for Benzidine

Healthcare Provider Resources

Symptoms of Benzidine

Causes & Risk Factors for Benzidine

Diagnostic studies for Benzidine

Treatment of Benzidine

Continuing Medical Education (CME)

CME Programs on Benzidine

International

Benzidine en Espanol

Benzidine en Francais

Business

Benzidine in the Marketplace

Patents on Benzidine

Experimental / Informatics

List of terms related to Benzidine


Overview

Benzidine is the trivial name for 4,4'-diaminobiphenyl, a carcinogenic aromatic amine which has been used as part of a test for cyanide and also in the synthesis of dyes. It has been linked to bladder cancer and pancreatic cancer.

In common with benzidine some other aromatic amines such as 2-aminonaphthalene have been withdrawn from use in almost all industries because they are so carcinogenic.

In the past a common test for blood used benzidine but this has largely been replaced by tests using phenolphthalein / hydrogen peroxide and luminol. An enzyme in blood causes the benzidine to be oxidized to a polymer which is blue coloured. The test for cyanide uses similar chemistry to give the blue colour.

Benzidine is a known human carcinogen. [1]

Benzidine rearrangement

In a classic rearrangement reaction called the benzidine rearrangement benzidine is formed by reaction of the 1,2-diphenylhydrazine (PhNHNHPh) with acids. One plausible reaction mechanism has both hydrazine nitrogen atoms protonated after which a sigmatropic reaction takes place [2].

External links

References

  1. www.cancer.org Link
  2. Advanced Organic Chemistry third edition Jerry March ISBN 047185472-7

de:Benzidin nl:Benzidine

Template:WikiDoc Sources