Behçet's disease natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
The symptoms of Behçet disease usually develop in the second to third decade of life, and start with symptoms such as uveitis, mouth sores, and skin lesions. Common complications of Behçet disease include neuro Behçet, vision loss, and aneurysm. Depending on the extent of the disease at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good. The worst prognoses are associated with retinal vasculitis, leading to blindness; vascular aneurysm formation, with possible rupture; and neuro–Behçet syndrome, which may lead to dementia despite appropriate aggressive treatment.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of Behçet disease usually develop in the second to third decade of life, and start with symptoms such as uveitis, mouth sores, and skin lesions.[1]
Complications
- Common complications of Behçet disease include:[2]
- Neuro Behçet
- Vision loss
- Aneurysm
Prognosis
- Depending on the extent of the disease at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.[3]
- The worst prognoses are associated with retinal vasculitis, leading to blindness; vascular aneurysm formation, with possible rupture; and neuro–Behçet syndrome, which may lead to dementia despite appropriate aggressive treatment.
References
- ↑ Sakane T, Takeno M, Suzuki N, Inaba G (1999). "Behçet's disease". N Engl J Med. 341 (17): 1284–91. doi:10.1056/NEJM199910213411707. PMID 10528040.
- ↑ Zouboulis CC, Vaiopoulos G, Marcomichelakis N, Palimeris G, Markidou I, Thouas B; et al. (2003). "Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades-Behçet's disease in Greece". Clin Exp Rheumatol. 21 (4 Suppl 30): S19–26. PMID 14727454.
- ↑ Sota J, Vitale A, Orlando I, Lopalco G, Franceschini R, Fabiani C; et al. (2017). "Auditory involvement in Behcet's disease: relationship with demographic, clinical, and therapeutic characteristics". Clin Rheumatol. 36 (2): 445–449. doi:10.1007/s10067-016-3367-x. PMID 27475793.