Bactericidal/permeability increasing protein

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bactericidal/permeability-increasing protein
Identifiers
SymbolBPI
Entrez671
HUGO1095
OMIM109195
RefSeqNM_001725
UniProtP17213
Other data
LocusChr. 20 q11.23

Bactericidal/permeability increasing protein is a bactericidal protein in neutrophil granulocytes.

External links

The bactericidal/permeability-increasing protein (BPI) is an endogenous antibiotic protein used by neutrophils to kill certain types of bacteria. It also binds to compounds called lipopolysaccharides that are produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the innate immune system, however BPI at certain concentrations can prevent this activation.

BPI was discovered by Jerrold Weiss and Peter Elsbach at New York University Medical School.



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