Bactericidal/permeability increasing protein
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- bactericidal+permeability+increasing+protein at the US National Library of Medicine Medical Subject Headings (MeSH)
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The bactericidal/permeability-increasing protein (BPI) is an endogenous antibiotic protein used by neutrophils to kill certain types of bacteria. It also binds to compounds called lipopolysaccharides that are produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the innate immune system, however BPI at certain concentrations can prevent this activation.
BPI was discovered by Jerrold Weiss and Peter Elsbach at New York University Medical School.