BMF (gene)

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

Bcl-2-modifying factor is a protein that in humans is encoded by the BMF gene.[1][2]

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

Interactions

BMF (gene) has been shown to interact with Bcl-2[1] and DYNLL2.[1][3]

References

  1. 1.0 1.1 1.2 Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A (Sep 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–32. doi:10.1126/science.1062257. PMID 11546872.
  2. 2.0 2.1 "Entrez Gene: BMF Bcl2 modifying factor".
  3. Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (Feb 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. England. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

Further reading

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