Axotomy
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The process of cutting or to otherwise sever an axon. Derived from axo- (=axon) and -tomy (=surgery). This type of denervation is often used in experimental studies on neuronal physiology and neuronal death or survival as a method to better understand nervous system diseases.[1]
Axotomy may cause neuronal cell death, espeically in embryonic or neonatal animals, as this is the period in which neurons are dependent on their targets for the supply of survival factors. But in mature animals, where survival factors are derived locally or via autocrine loops, axotomy of peripheral neurons and motoneurons can lead to a robust regenerative response without any neuronal death. In both cases, autophagy is observed to markedly increase. Autophagy could either clear the way for neuronal degeneration or it could be a medium for cell destruction.[2]
See also
References
- ↑ "Online Medical Dictionary"
- ↑ Rubinsztein DC et al. (2005) Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22. PMID 16874045
Surgery, Nervous system: neurosurgical procedures | |
|---|---|
| Skull, brain, and cerebral meninges | Craniotomy - Decompressive craniectomy - Lobotomy - Hemispherectomy - Ventriculostomy - Anterior temporal lobectomy |
| Spinal cord and spinal canal | Spinal cord and roots (Cordotomy - Rhizotomy) - Intervertebral discs (Discectomy - Intervertebral disc annuloplasty - Intervertebral disc arthroplasty) - Vertebral bones (Laminotomy - Laminectomy - Laminoplasty - Corpectomy - Facetectomy - Foraminotomy - Vertebral fusion - Vertebral fixation) - Lumbar puncture |
| Cranial and peripheral nerves | Ganglionectomy - Nerve block |
| Sympathetic nerves or ganglia | Endoscopic thoracic sympathectomy |
| Other | Axotomy - Hypophysectomy - Vagotomy |
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