Autoimmune retinopathy history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Overview

Symptoms of autoimmune retinopathy depends on the type of retinal cell dysfunction. Cones dysfunction results in, photosensitivity, hemeralopia (inability to see as clearly in bright light), colour vision deficit, decreased visual acuity and central vision loss. Rods dysfunction results in, nyctalopia (night blindness), prolonged dark adaptation, and loss of peripheral vision. Photopsia is associated with dysfunction of both Rods and cones.

Non-neoplastic and neoplastic retinopathy has cones, rods or both cellular dysfunction. Cancer associated retinopathy is associated with both cones and rods dysfunction. Melanoma associated retinopathy is associated with rods dysfunction, and antibodies against bipolar cells.

History

Symptoms

The symptoms of Autoimmune retinopathy (AIR), is associated with the type of retinal cells that are affected.  Cellular dysfunction of rods and cones vary in the symptoms that they produce.

Retinal cell dysfunction and associated symptoms
Retinal cell dysfunction Associated symptoms
Cones Diminished vision acuity, diminished central vision, loss of colour vision, photopsia, photosensitivity, hemeralopia
Rods Prolonged dark adaptation, peripheral vision field loss, photopsia, nyctalopia
Autoimmune retinopathy and associated cell dysfunction
Type of Autoimmune Retinopathy Cellular dysfunction
Non-paraneoplastic Cones or rods or both
Paraneoplastic Cones or rods or both
Cancer associated retinopathy Cones and rods
Melanoma associated retinopathy Rods, antibodies against bipolar cells
  • Cones dysfunction results in, photosensitivity, hemeralopia (inability to see as clearly in bright light), colour vision deficit, decreased visual acuity and central vision loss.
  • Rods dysfunction results in, nyctalopia (night blindness), prolonged dark adaptation, and loss of peripheral vision.
  • Photopsia is associated with dysfunction of both rods and cones.[1]

References

  1. Canamary AM, Takahashi WY, Sallum JMF (2018). "Autoimmune retinopathy: A Review". Int J Retina Vitreous. 4: 1. doi:10.1186/s40942-017-0104-9. PMC 5759752. PMID 29340169.


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