Ascending cholangitis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anila Hussain, MD [2]

Overview

Common risk factors in the development of ascending cholangitis include bile duct stones, history of gall stones, biliary strictures, and biliary tract surgery. Less common factors include immunodeffeciency, comorbidities and sclerosing cholangitis. There is a higher risk of acute cholangitis in patients with advanced age (>70) and smoking.

Risk Factors

There are multiple factors that predispose a person to develop ascending or acute cholangitis. Some of these are as follows:

Common Risk Factors

  • Common risk factors in the development of ascending cholangitis may be occupational, environmental, genetic, and viral.
  • Common risk factors in the development of ascending cholangitis include:[1][2]
    • Advanced age (more than 70 year's)
    • Chronic smoking
    • Gall stones
    • Impacted bile duct stones
    • Benign or malignant stricture
    • Biliary tract surgery[3]
    • ERCP[4]

Less Common Risk Factors

References

  1. Yeom DH, Oh HJ, Son YW, Kim TH (2010). "What are the risk factors for acute suppurative cholangitis caused by common bile duct stones?". Gut Liver. 4 (3): 363–7. doi:10.5009/gnl.2010.4.3.363. PMC 2956349. PMID 20981214.
  2. Gigot JF, Leese T, Dereme T, Coutinho J, Castaing D, Bismuth H (1989). "Acute cholangitis. Multivariate analysis of risk factors". Ann Surg. 209 (4): 435–8. PMC 1493983. PMID 2930289.
  3. Cybulski Z, Solarski J, Majewski W (1994). "[Infection as a risk factor in biliary system surgery]". Wiad Lek. 47 (15–16): 619–24. PMID 7716962.
  4. Sauter G, Ruckdeschel G, Sauerbruch T (1992). "[Antibiotic prevention and therapy of infectious complications in ERCP]". Leber Magen Darm. 22 (5): 173–6. PMID 1406012.
  5. Tsujino T, Sugita R, Yoshida H, Yagioka H, Kogure H, Sasaki T; et al. (2007). "Risk factors for acute suppurative cholangitis caused by bile duct stones". Eur J Gastroenterol Hepatol. 19 (7): 585–8. doi:10.1097/MEG.0b013e3281532b78. PMID 17556906.

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