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In enzymology, an arylacetonitrilase (EC is an enzyme that catalyzes the chemical reaction

4-chlorophenylacetonitrile + 2 H2O 4-chlorophenylacetate + NH3

Thus, the two substrates of this enzyme are 4-chlorophenylacetonitrile and H2O, whereas its two products are 4-chlorophenylacetate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is arylacetonitrile aminohydrolase. This enzyme participates in cyanoamino acid metabolism.


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  • Mauger J, Nagasawa T and Yamada H (1990). "Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes faecalis JM3". Arch. Microbiol. 155: 1&ndash, 6.
  • Nagasawa T, Mauger J, Yamada H (1990). "A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3 Purification and characterization". Eur. J. Biochem. 194: 765&ndash, 72. PMID 2269298.

External links

The CAS registry number for this enzyme class is 132053-06-6.

Gene Ontology (GO) codes