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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Antianalgesia is the ability of some endogenous chemicals (notably cholecystokinin and neuropeptide Y) to counter the effects of exogenous analgesics (such as morphine) or endogenous pain inhibiting neurotransmitters/modulators, such as the endogenous opioids.[1] A learned form can be established using methods similar to the learning principle of conditioned inhibition, and has been demonstrated in rats.


  1. Wiertelak, EP (1992). "Cholecystokinin antianalgesia: safety cues abolish morphine analgesia". Science. 256 (5058): 830–833. doi:10.1126/science.1589765. Retrieved 2007-02-12. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)