Anti-p62 antibodies
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| Autoantibody(s) | |
|---|---|
| Anti-p62 | |
| Autoantigen Isoform | Nucleoporin 62kDA |
| Autoantigen gene | NUP62 |
| Affected organ(s) | Bile Duct |
| AssociatedDisease(s) | Primary biliary cirrhosis |
| HLA associations | DR2 (weak) |
Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.[1] p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.[2][3] The autoantigen is the nucleoporin 62kDA protein.
References
- ↑ Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology 110 (3): 840-7. PMID 8608894.
- ↑ Miyachi K, Hankins RW, Matsushima H, et al (2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study". J. Autoimmun. 20 (3): 247-54. PMID 12753810.
- ↑ Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". Semin. Liver Dis. 25 (3): 298-310. doi:10.1055/s-2005-916321. PMID 16143945.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
