Aldose-6-phosphate reductase (NADPH)

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In enzymology, an aldose-6-phosphate reductase (NADPH) (EC is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NADP+ D-glucose 6-phosphate + NADPH + H+

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NADP+, whereas its 3 products are D-glucose 6-phosphate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-aldose-6-phosphate:NADP+ 1-oxidoreductase. Other names in common use include aldose 6-phosphate reductase, NADP+-dependent aldose 6-phosphate reductase, A6PR, aldose-6-P reductase, aldose-6-phosphate reductase, alditol 6-phosphate:NADP+ 1-oxidoreductase, and aldose-6-phosphate reductase (NADPH).


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Negm FB and Loescher WH (1981). "Characterization and partial-purification of aldose-6-phosphate reductase (alditol-6-phosphate-NADP 1-oxidoreductase) from apple leaves". Plant Physiol. 67: 139&ndash, 142.

External links

The CAS registry number for this enzyme class is 76901-04-7.

Gene Ontology (GO) codes