Adenylyl-(glutamate-ammonia ligase) hydrolase

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In enzymology, an adenylyl-[glutamate---ammonia ligase] hydrolase (EC is an enzyme that catalyzes the chemical reaction

adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O adenylate + [L-glutamate:ammonia ligase (ADP-forming)]

Thus, the two substrates of this enzyme are [[adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]]] and H2O, whereas its two products are adenylate and [[[L-glutamate:ammonia ligase (ADP-forming)]]].

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] adenylylhydrolase. Other names in common use include adenylyl-[glutamine-synthetase]hydrolase, and adenylyl(glutamine synthetase) hydrolase.


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  • Heilmeyer L, Battig F and Holzer H (1968). "Characterization of a glutamine synthetase b activating (deadenylylating) enzyme system in Escherichia coli". Eur. J. Biochem. 9: 259&ndash, 262.
  • Shapiro BM (1969). "The glutamine synthetase deadenylylating enzyme system from Escherichia coli. Resolution into two components, specific nucleotide stimulation, and cofactor requirements". Biochemistry. 8: 659&ndash, 70. PMID 4893578.
  • Shapiro BM, Stadtman ER (1968). "5'-adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from Escherichia coli". J. Biol. Chem. 243: 3769&ndash, 71. PMID 4298074.

External links

The CAS registry number for this enzyme class is 37288-22-5.

Gene Ontology (GO) codes