Acute eosinophilic leukemia
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| Acute eosinophilic leukemia Classification and external resources | |
| ICD-O: | M9880/3 |
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| MeSH | D015472 |
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Acute eosinophilic leukemia (AEL) is a rare subtype of acute myeloid leukemia with 50 to 80 percent of eosinophilic cells in the blood and marrow. It can arise de novo or may develop in patients having the chronic form of a hypereosinophilic syndrome. Patients with acute eosinophilic leukemia have a propensity for developing bronchospasm and heart failure from endomyocardial fibrosis. Hepatomegaly and splenomegaly are more common than in other variants of AML.
Diagnosis
A specific histochemical reaction, cyanide-resistant peroxidase, permits identification of leukemic blast cells with eosinophilic differentiation and diagnosis of acute eosinoblastic leukemia in some cases of AML with few identifiable eosinophils in blood or marrow.
Treatment and Prognosis
Acute eosinophilic leukemia is treated as other subtypes of AML. Response to treatment is approximately the same as in other types of AML.
References
- Williams Hematology, McGraw-Hill, 7th ed, 2005.
Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208) | |||||||||||||||
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| CFU-GM/ and other granulocytes |
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| MEP |
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| CFU-Mast | Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis) | ||||||||||||||
| Multiple/unknown | AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia | ||||||||||||||
| See also hematology, lymphoid malignancy | |||||||||||||||
WikiDoc Research Resources for Acute eosinophilic leukemia | |
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| Articles on Acute eosinophilic leukemia | Most recent articles on Acute eosinophilic leukemia • Most cited articles on Acute eosinophilic leukemia • Review articles on Acute eosinophilic leukemia • Articles on Acute eosinophilic leukemia in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Acute eosinophilic leukemia | Powerpoint slides on Acute eosinophilic leukemia • Images of Acute eosinophilic leukemia • Photos of Acute eosinophilic leukemia • Podcasts & MP3s on Acute eosinophilic leukemia • Videos on Acute eosinophilic leukemia |
| Evidence Based Medicine Regarding Acute eosinophilic leukemia | Cochrane Collaboration on Acute eosinophilic leukemia • Bandolier on Acute eosinophilic leukemia • TRIP on Acute eosinophilic leukemia |
| Cost Effectiveness of Acute eosinophilic leukemia | Cost Effectiveness of Acute eosinophilic leukemia |
| Clinical Trials Involving Acute eosinophilic leukemia | Ongoing Trials on Acute eosinophilic leukemia at Clinical Trials.gov • Trial results on Acute eosinophilic leukemia • Clinical Trials on Acute eosinophilic leukemia at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Acute eosinophilic leukemia | US National Guidelines Clearinghouse on Acute eosinophilic leukemia • NICE Guidance on Acute eosinophilic leukemia • NHS PRODIGY Guidance • FDA on Acute eosinophilic leukemia • CDC on Acute eosinophilic leukemia |
| Textbook Information on Acute eosinophilic leukemia | Books and Textbook Information on Acute eosinophilic leukemia |
| Pharmacology Resources on Acute eosinophilic leukemia | Dosing of Acute eosinophilic leukemia • Drug interactions with Acute eosinophilic leukemia • Side effects of Acute eosinophilic leukemia • Allergic reactions to Acute eosinophilic leukemia • Overdose information on Acute eosinophilic leukemia • Carcinogenicity information on Acute eosinophilic leukemia • Acute eosinophilic leukemia in pregnancy • Pharmacokinetics of Acute eosinophilic leukemia • |
| Genetics, Pharmacogenomics, and Proteinomics of Acute eosinophilic leukemia | Genetics of Acute eosinophilic leukemia • Pharmacogenomics of Acute eosinophilic leukemia • Proteomics of Acute eosinophilic leukemia |
| Newstories on Acute eosinophilic leukemia | Acute eosinophilic leukemia in the news • Be alerted to news on Acute eosinophilic leukemia • News trends on Acute eosinophilic leukemia |
| Commentary on Acute eosinophilic leukemia | Blogs on Acute eosinophilic leukemia |
| Patient Resources on Acute eosinophilic leukemia | Patient resources on Acute eosinophilic leukemia • Discussion groups on Acute eosinophilic leukemia • Patient Handouts on Acute eosinophilic leukemia • Directions to Hospitals Treating Acute eosinophilic leukemia • Risk calculators and risk factors for Acute eosinophilic leukemia |
| Healthcare Provider Resources on Acute eosinophilic leukemia | Symptoms of Acute eosinophilic leukemia • Causes & Risk Factors for Acute eosinophilic leukemia • Diagnostic studies for Acute eosinophilic leukemia • Treatment of Acute eosinophilic leukemia |
| Continuing Medical Education (CME) Programs on Acute eosinophilic leukemia | CME Programs on Acute eosinophilic leukemia |
| International Resources on Acute eosinophilic leukemia | Acute eosinophilic leukemia en Espanol • Acute eosinophilic leukemia en Francais |
| Business Resources on Acute eosinophilic leukemia | Acute eosinophilic leukemia in the Marketplace • Patents on Acute eosinophilic leukemia |
| Informatics Resources on Acute eosinophilic leukemia | List of terms related to Acute eosinophilic leukemia |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
