Acid-CoA ligase (GDP-forming)

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In enzymology, an acid-CoA ligase (GDP-forming) (EC is an enzyme that catalyzes the chemical reaction

GTP + an acid + CoA GDP + phosphate + acyl-CoA

The 3 substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acid:CoA ligase (GDP-forming). Other names in common use include acyl-CoA synthetase (GDP-forming), and acyl coenzyme A synthetase (guanosine diphosphate forming).


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Rossi CR and Gibson DM (1964). "Activation of fatty acids by a guanosine triphosphate-specific thiokinase from liver mitochondria". J. Biol. Chem. 239: 1694&ndash, 1699.

External links

The CAS registry number for this enzyme class is 37318-59-5.

Gene Ontology (GO) codes