Abelson leukemia virus protein

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v-abl Abelson murine leukemia viral oncogene homolog 1
Identifiers
SymbolABL1
Alt. symbolsABL
Entrez25
HUGO76
OMIM189980
RefSeqNM_007313
UniProtP00519
Other data
LocusChr. 9 q34.1

Abl (Abelson leukemia virus protein, chromosome 9q34) is an important tyrosine kinase. This gene is fused with the bcr gene in a Philadelphia chromosome, the characteristic abnormality in chronic myelogenous leukemia (CML) and rarely in some other leukemia forms. The bcr-abl transcript is also a tyrosine kinase, which activates mediators of the cell cycle regulation system, leading to a clonal myeloproliferative disorder. The bcr-abl protein can be inhibited with the agent imatinib mesylate, which occupies the TK domain and inhibits bcr-abls influence on the cell cycle.

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