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Adducin 1 (alpha)
Symbol(s) ADD1; ADDA; MGC3339; MGC44427
External IDs OMIM: 102680 MGI87918 Homologene22758
RNA expression pattern




More reference expression data

Human Mouse
Entrez 118 11518
Ensembl ENSG00000087274 ENSMUSG00000029106
Uniprot na Q8BJT2
Refseq NM_001119 (mRNA)
NP_001110 (protein)
NM_001024458 (mRNA)
NP_001019629 (protein)
Location Chr 4: 2.82 - 2.9 Mb Chr 5: 34.89 - 34.95 Mb
Pubmed search [1] [2]

Adducin 1 (alpha), also known as ADD1, is a human gene.[1]

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.[1]


Further reading

  • Mangeat PH (1989). "Interaction of biological membranes with the cytoskeletal framework of living cells.". Biol. Cell. 64 (3): 261–81. PMID 2976282. 
  • Matsuoka Y, Li X, Bennett V (2000). "Adducin: structure, function and regulation.". Cell. Mol. Life Sci. 57 (6): 884–95. PMID 10950304. 
  • Goldberg YP, Lin BY, Andrew SE; et al. (1993). "Cloning and mapping of the alpha-adducin gene close to D4S95 and assessment of its relationship to Huntington disease.". Hum. Mol. Genet. 1 (9): 669–75. PMID 1284592. 
  • Taylor SA, Snell RG, Buckler A; et al. (1994). "Cloning of the alpha-adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification.". Nat. Genet. 2 (3): 223–7. PMID 1345173. doi:10.1038/ng1192-223. 
  • Joshi R, Gilligan DM, Otto E; et al. (1991). "Primary structure and domain organization of human alpha and beta adducin.". J. Cell Biol. 115 (3): 665–75. PMID 1840603. 
  • Gardner K, Bennett V (1987). "Modulation of spectrin-actin assembly by erythrocyte adducin.". Nature. 328 (6128): 359–62. PMID 3600811. doi:10.1038/328359a0. 
  • Gilligan DM, Lieman J, Bennett V (1996). "Assignment of the human beta-adducin gene (ADD2) to 2p13-p14 by in situ hybridization.". Genomics. 28 (3): 610–2. PMID 7490111. doi:10.1006/geno.1995.1205. 
  • Lin B, Nasir J, McDonald H; et al. (1995). "Genomic organization of the human alpha-adducin gene and its alternately spliced isoforms.". Genomics. 25 (1): 93–9. PMID 7774961. 
  • Nasir J, Lin B, Bucan M; et al. (1994). "The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3.". Genomics. 22 (1): 198–201. PMID 7959767. doi:10.1006/geno.1994.1361. 
  • Kuhlman PA, Hughes CA, Bennett V, Fowler VM (1996). "A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments.". J. Biol. Chem. 271 (14): 7986–91. PMID 8626479. 
  • Li X, Bennett V (1996). "Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes.". J. Biol. Chem. 271 (26): 15695–702. PMID 8663089. 
  • Matsuoka Y, Hughes CA, Bennett V (1996). "Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.". J. Biol. Chem. 271 (41): 25157–66. PMID 8810272. 
  • Hadano S, Ishida Y, Tomiyasu H; et al. (1997). "Transcript map of the human chromosome 4p16.3 consisting of 627 cDNA clones derived from 1 Mb of the Huntington's disease locus.". DNA Res. 3 (4): 239–55. PMID 8946164. 
  • Cusi D, Barlassina C, Azzani T; et al. (1997). "Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension.". Lancet. 349 (9062): 1353–7. PMID 9149697. 
  • Kamitani A, Wong ZY, Fraser R; et al. (1998). "Human alpha-adducin gene, blood pressure, and sodium metabolism.". Hypertension. 32 (1): 138–43. PMID 9674650. 
  • Matsuoka Y, Li X, Bennett V (1998). "Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.". J. Cell Biol. 142 (2): 485–97. PMID 9679146. 
  • Fukata Y, Oshiro N, Kinoshita N; et al. (1999). "Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.". J. Cell Biol. 145 (2): 347–61. PMID 10209029. 
  • Halushka MK, Fan JB, Bentley K; et al. (1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.". Nat. Genet. 22 (3): 239–47. PMID 10391210. doi:10.1038/10297. 
  • Ferrandi M, Salardi S, Tripodi G; et al. (1999). "Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension.". Am. J. Physiol. 277 (4 Pt 2): H1338–49. PMID 10516168.