ADAM9

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ADAM metallopeptidase domain 9 (meltrin gamma)
Identifiers
Symbol(s) ADAM9; MCMP; KIAA0021; MDC9; Mltng
External IDs OMIM: 602713 MGI105376 Homologene20824
Orthologs
Human Mouse
Entrez 8754 11502
Ensembl ENSG00000168615 ENSMUSG00000031555
Uniprot Q13443 Q3UG15
Refseq NM_001005845 (mRNA)
NP_001005845 (protein)
NM_007404 (mRNA)
NP_031430 (protein)
Location Chr 8: 38.97 - 39.08 Mb Chr 8: 26.42 - 26.48 Mb
Pubmed search [1] [2]

ADAM metallopeptidase domain 9 (meltrin gamma), also known as ADAM9, is a human gene.[1]


This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.[1]


References

Further reading

  • Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. PMID 7584026. 
  • Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. PMID 7584028. 
  • Weskamp G, Krätzschmar J, Reid MS, Blobel CP (1996). "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.". J. Cell Biol. 132 (4): 717–26. PMID 8647900. 
  • McKie N, Dallas DJ, Edwards T; et al. (1996). "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.". Biochem. J. 318 ( Pt 2): 459–62. PMID 8809033. 
  • McKie N, Edwards T, Dallas DJ; et al. (1997). "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes.". Biochem. Biophys. Res. Commun. 230 (2): 335–9. PMID 9016778. doi:10.1006/bbrc.1996.5957. 
  • Izumi Y, Hirata M, Hasuwa H; et al. (1999). "A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.". EMBO J. 17 (24): 7260–72. PMID 9857183. doi:10.1093/emboj/17.24.7260. 
  • Roghani M, Becherer JD, Moss ML; et al. (1999). "Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.". J. Biol. Chem. 274 (6): 3531–40. PMID 9920899. 
  • Nelson KK, Schlöndorff J, Blobel CP (2000). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.". Biochem. J. 343 Pt 3: 673–80. PMID 10527948. 
  • Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.". J. Biol. Chem. 274 (44): 31693–9. PMID 10531379. 
  • Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin.". Biochem. Biophys. Res. Commun. 280 (2): 574–80. PMID 11162558. doi:10.1006/bbrc.2000.4155. 
  • Namba K, Nishio M, Mori K; et al. (2002). "Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes.". Cell. Immunol. 213 (2): 104–13. PMID 11831872. doi:10.1006/cimm.2001.1873. 
  • Eto K, Huet C, Tarui T; et al. (2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.". J. Biol. Chem. 277 (20): 17804–10. PMID 11882657. doi:10.1074/jbc.M200086200. 
  • Lim JM, Lee JH, Wee WR, Joo CK (2002). "Downregulated expression of ADAM9 in anterior polar cataracts.". Journal of cataract and refractive surgery. 28 (4): 697–702. PMID 11955914. 
  • Hotoda N, Koike H, Sasagawa N, Ishiura S (2002). "A secreted form of human ADAM9 has an alpha-secretase activity for APP.". Biochem. Biophys. Res. Commun. 293 (2): 800–5. PMID 12054541. doi:10.1016/S0006-291X(02)00302-9. 
  • Amour A, Knight CG, English WR; et al. (2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.". FEBS Lett. 524 (1-3): 154–8. PMID 12135759. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Mohan S, Thompson GR, Amaar YG; et al. (2003). "ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts.". Biochemistry. 41 (51): 15394–403. PMID 12484779. 
  • Asai M, Hattori C, Szabó B; et al. (2003). "Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.". Biochem. Biophys. Res. Commun. 301 (1): 231–5. PMID 12535668. 
  • O'Shea C, McKie N, Buggy Y; et al. (2003). "Expression of ADAM-9 mRNA and protein in human breast cancer.". Int. J. Cancer. 105 (6): 754–61. PMID 12767059. doi:10.1002/ijc.11161. 
  • Grützmann R, Lüttges J, Sipos B; et al. (2004). "ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma.". Br. J. Cancer. 90 (5): 1053–8. PMID 14997207. doi:10.1038/sj.bjc.6601645. 
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