6-oxohexanoate dehydrogenase

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In enzymology, a 6-oxohexanoate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

6-oxohexanoate + NADP+ + H2O adipate + NADPH + 2 H+

The 3 substrates of this enzyme are 6-oxohexanoate, NADP+, and H2O, whereas its 3 products are adipate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-oxohexanoate:NADP+ oxidoreductase. This enzyme participates in caprolactam degradation.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74: 115&ndash, 27. PMID 856571.
  • Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60: 1&ndash, 7. PMID 1261.

External links

Gene Ontology (GO) codes