5,10-methenyltetrahydromethanopterin hydrogenase

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In enzymology, a 5,10-methenyltetrahydromethanopterin hydrogenase (EC is an enzyme that catalyzes the chemical reaction

H2 + 5,10-methenyltetrahydromethanopterin H+ + 5,10-methylenetetrahydromethanopterin

Thus, the two substrates of this enzyme are H2 and 5,10-methenyltetrahydromethanopterin, whereas its two products are H+ and 5,10-methylenetetrahydromethanopterin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with other, known, acceptors. The systematic name of this enzyme class is hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase. Other names in common use include H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, nonmetal hydrogenase, N5,N10-methenyltetrahydromethanopterin hydrogenase, and hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2B0J.


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  • Zirngibl C, Hedderich R and Thauer RK (1990). "N5,N10-Methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautotrophicum has hydrogenase activity". FEBS Lett. 261: 112&ndash, 116.
  • Klein AR, Fernandez VM, Thauer RK (1995). "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase: mechanism of H2 formation analyzed using hydrogen isotopes". FEBS. Lett. 368: 203&ndash, 6. PMID 7628605.

External links

The CAS registry number for this enzyme class is 100357-01-5.

Gene Ontology (GO) codes