4-methyleneglutamate-ammonia ligase

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In enzymology, a 4-methyleneglutamate-ammonia ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + 4-methylene-L-glutamate + NH3 AMP + diphosphate + 4-methylene-L-glutamine

The 3 substrates of this enzyme are ATP, 4-methylene-L-glutamate, and NH3, whereas its 3 products are AMP, diphosphate, and 4-methylene-L-glutamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is 4-methylene-L-glutamate:ammonia ligase (AMP-forming). This enzyme is also called 4-methyleneglutamine synthetase. This enzyme participates in c5-branched dibasic acid metabolism.


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  • Winter HC, Su TZ, Dekker EE (1983). "4-methyleneglutamine synthetase: a new amide synthetase present in germinating peanuts". Biochem. Biophys. Res. Commun. 111: 484&ndash, 9. PMID 6838571.

External links

The CAS registry number for this enzyme class is 85537-85-5.

Gene Ontology (GO) codes