4-hydroxymuconic-semialdehyde dehydrogenase

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In enzymology, a 4-hydroxymuconic-semialdehyde dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

4-hydroxymuconic semialdehyde + NAD+ + H2O maleylacetate + NADH + 2 H+

The 3 substrates of this enzyme are 4-hydroxymuconic semialdehyde, NAD+, and H2O, whereas its 3 products are maleylacetate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme participates in gamma-hexachlorocyclohexane degradation.


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  • Spain JC, Gibson DT (1991). "Pathway for Biodegradation of p-Nitrophenol in a Moraxella sp". Appl. Environ. Microbiol. 57: 812&ndash, 819. PMID 16348446.

External links

Gene Ontology (GO) codes