4-aminobenzoate 1-monooxygenase

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In enzymology, a 4-aminobenzoate 1-monooxygenase (EC is an enzyme that catalyzes the chemical reaction

4-aminobenzoate + NAD(P)H + 2 H+ + O2 4-hydroxyaniline + NAD(P)+ + H2O + CO2

The 5 substrates of this enzyme are 4-aminobenzoate, NADH, NADPH, H+, and O2, whereas its 5 products are 4-hydroxyaniline, NAD+, NADP+, H2O, and CO2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating). Other names in common use include 4-aminobenzoate hydroxylase, and 4-aminobenzoate monooxygenase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, FAD.


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  • Tsuji H, Ogawa T, Bando N, Sasaoka K (1986). "Purification and properties of 4-aminobenzoate hydroxylase, a new monooxygenase from Agaricus bisporus". J. Biol. Chem. 261: 13203&ndash, 9. PMID 3489713.

External links

The CAS registry number for this enzyme class is 98668-55-4.

Gene Ontology (GO) codes