3-oxo-5beta-steroid 4-dehydrogenase

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In enzymology, a 3-oxo-5beta-steroid 4-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

a 3-oxo-5beta-steroid + acceptor a 3-oxo-Delta4-steroid + reduced acceptor

Thus, the two substrates of this enzyme are 3-oxo-5beta-steroid and acceptor, whereas its two products are 3-oxo-Delta4-steroid and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase. This enzyme is also called 3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase. This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Davidson SJ, Talalay P (1966). "Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase". J. Biol. Chem. 241: 906&ndash, 15. PMID 5907467.

External links

The CAS registry number for this enzyme class is 9067-97-4.

Gene Ontology (GO) codes