3-hydroxybutyryl-CoA dehydrogenase

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In enzymology, a 3-hydroxybutyryl-CoA dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoyl-CoA + NADP+ 3-acetoacetyl-CoA + NADPH + H+

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoyl-CoA and NADP+, whereas its 3 products are 3-acetoacetyl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase. Other names in common use include beta-hydroxybutyryl coenzyme A dehydrogenase, L(+)-3-hydroxybutyryl-CoA dehydrogenase, BHBD, dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine, dinucleotide phosphate), L-(+)-3-hydroxybutyryl-CoA dehydrogenase, and beta-hydroxybutyryl-CoA dehydrogenase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.


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  • Madan VK, Hillmer P, Gottschalk G (1973). "Purification and properties of NADP-dependent L(+)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium kluyveri". Eur. J. Biochem. 32: 51&ndash, 6. PMID 4405720.

External links

The CAS registry number for this enzyme class is 39319-78-3.

Gene Ontology (GO) codes