3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

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In enzymology, a 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine S-adenosyl-L-homocysteine + (S)-reticuline

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-hydroxy-N-methyl-(S)-coclaurine, whereas its two products are S-adenosylhomocysteine and (S)-reticuline.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.


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  • Frenzel T, Zenk MH (1990). "S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway". Phytochemistry. 29: 3505&ndash, 3511.

External links

The CAS registry number for this enzyme class is 132084-81-2.

Gene Ontology (GO) codes