2-hydroxyquinoline 5,6-dioxygenase

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In enzymology, a 2-hydroxyquinoline 5,6-dioxygenase (EC is an enzyme that catalyzes the chemical reaction

quinolin-2-ol + NADH + H+ + O2 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+

The 4 substrates of this enzyme are quinolin-2-ol, NADH, H+, and O2, whereas its two products are 2,5,6-trihydroxy-5,6-dihydroquinoline and NAD+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating). Other names in common use include 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase, quinolin-2-ol 5,6-dioxygenase, and quinolin-2(1H)-one 5,6-dioxygenase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Schach S, Tshisuaka B, Fetzner S, Lingens F (1995). "Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation". Eur. J. Biochem. 232: 536&ndash, 44. PMID 7556204.

External links

The CAS registry number for this enzyme class is 172399-50-7.

Gene Ontology (GO) codes