2-(S)-hydroxypropyl-CoM dehydrogenase

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In enzymology, a 2-(S)-hydroxypropyl-CoM dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

2-(S)-hydroxypropyl-CoM + NAD+ 2-oxopropyl-CoM + NADH + H+

Thus, the two substrates of this enzyme are 2-(S)-hydroxypropyl-CoM and NAD+, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase. This enzyme is also called 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase.


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  • Allen JR, Clark DD, Krum JG, Ensign SA (1999). "A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation". Proc. Natl. Acad. Sci. U. S. A. 96: 8432&ndash, 7. PMID 10411892.

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Gene Ontology (GO) codes